FAQ : [website security certificate Problem]
Introduction：Glucose-6-phosphate dehydrogenase (G6PD; EC1.1.1.49; MIM305900) deficiency is the most common enzymopathic in humans. A relatively high incidence (>2%) of this enzymopathy, which may cause of neonatal jaundice and acute hemolytic anemia, was found in Southeast Asia. If it is not prevented or treated properly, neonatal jaundice may lead to kernicterus and cause death or permanent neurological damage. The life-threatening hemolytic crises that occur later may cause permanent kidney damage and can be induced by certain drugs or by eating fava beans. In order to reduce these complications, neonatal screening for G6PD deficiency has been carried out in many countries in this region.
In order to assure the reliability and consistence of the G6PD neonatal screening and confirmatory tests among different laboratories, an external qaulity assurance (EQA) program for screening G6PD activity in neonatal dried blood spots and determination of G6PD activity in hemolysate has been carried out in Taiwan since 1988 and adopted by the Philippines neonatal screening program (Screening test since 1999).
For the EQA survey on the confirmatory quantitative test (determination of G6PD activity in hemolysate), periodically, three lyophilized QC materials were sent to each participating laboratory on dry ice by speed post delivery. The results of G6PD activity analysis were requested to be returned by facsimile and submitted by internet within 8 days. The external QA results were evaluated and compared to the median of all reports received and the reference value determined by the reference laboratory. The summary report for each survey was published on website within two weeks after the survey started.
Instruction to External Quality Assurance (EQA) for G6PD Quantitative Test
Participating
Laboratories
Results
:1. Survey No : RH2024-01 ( PDF )
2. Survey No : RH2024-02 ( PDF )
3. Survey No : RH2024-03 ( PDF )
*IMP : Intermediate Measurement Precision ( a.k.a within-laboratory precision ) ( JCGM 200 : 2012, VIM 3rd ed. ； ISO 3534-2:2006 )
Annual Summary Announcement Related to this G6PD EQA Programs
 |
Newborn
Screening QA Program
Preventive Medicine Foundation |
|
 |
||
| P.O. Box 624, Taipei Xinwei, Taiwan 10699 |  |
University of the Philippines Manila | |||
| Tel : + 886-2-2703-6080; Fax : +886-2-2703-6070 | Unit 104, Building A, UP Ayala Land Technohub, Brgy. UP Campus, |
||||
|
Fax : + 632-351-7903; |  |
|||
| updated : 09 Oct, 2024 |
|
||||
